The extracellular portion of c-MET is composed of three domain types. The c-MET receptor is formed by proteolytic processing of a common precursor in the post-Golgi compartment into a single-pass, disulphide-linked α/β heterodimer ( Figure 1a.). This cell surface receptor is expressed in epithelial cells of many organs, including the liver, pancreas, prostate, kidney, muscle and bone marrow, during both embryogenesis and adulthood. The protein product of this gene is the c-MET tyrosine kinase. Its transcription is regulated by Ets (E-twenty six), Pax3 (paired box 3), AP2 (activator protein-2) and Tcf-4 (transcription factor 4), and it is expressed as multiple mRNA transcripts of 8, 7, 4.5, 3 and 1.5 kilobases. The c- MET proto-oncogene is located on chromosome 7q21-31. Hepatocyte growth factor and c-MET: structure and function
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